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Improving blood compatibility of surfaces using tanfloc and carboxymethyl-kappa-carrageenan polyelectrolyte multilayers

dc.contributor.authorBaghersad, Somayeh, author
dc.contributor.authorKipper, Matt J., advisor
dc.contributor.authorPopat, Ketul C., advisor
dc.contributor.authorGhosh, Soham, committee member
dc.contributor.authorHerrera-Alonso, Margarita, committee member
dc.contributor.authorMartins, Alessandro F., committee member
dc.date.accessioned2025-06-02T15:21:14Z
dc.date.available2027-05-28
dc.date.issued2025
dc.descriptionZip file contains supplemental figures.
dc.description.abstractBlood-contacting medical devices are indispensable in modern medicine but often cause complications like thrombosis, infections, and undesirable cellular responses. This research addresses these challenges through surface modifications using bio-derived polymers and nanoscale topographies. The first aim focuses on developing polyelectrolyte multilayers (PEMs) using tanfloc (TAN), an amphoteric antimicrobial polymer, as both a polycation and polyanion. These PEMs showed strong antibacterial activity and excellent biocompatibility, providing a foundation for multifunctional coatings. The second aim investigates the hemocompatibility of TAN and carboxymethyl-kappa-carrageenan (CMKC) PEMs on titanium nanotube arrays (TiNT). Results demonstrated superior performance of CMKC compared to heparin (HEP) in reducing platelet adhesion, activation, and whole-blood clotting. Structural similarity of CMKC to HEP, coupled with its sustainable and animal-free origin, highlights its potential as a safer anticoagulant alternative. The third aim examines endothelialization and smooth muscle cell (SMC) modulation on TAN-CMKC-modified TiNT. These modifications enhanced endothelial cell adhesion, proliferation, and migration while significantly suppressing SMC proliferation and migration, critical for minimizing restenosis and promoting vascular healing. This research establishes TAN and CMKC-based PEMs as promising solutions for blood-contacting devices, offering improved thrombosis resistance, infection prevention, and support for vascular-related cellular interactions compared to current alternatives.
dc.format.mediumborn digital
dc.format.mediumdoctoral dissertations
dc.format.mediumZIP
dc.format.mediumPDF
dc.identifierBaghersad_colostate_0053A_18841.pdf
dc.identifier.urihttps://hdl.handle.net/10217/241040
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2020-
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.rights.accessEmbargo expires: 05/28/2027.
dc.subjecthemocompatibility
dc.subjectpolyelectrolyte multilayers
dc.subjecttanfloc
dc.subjectheparin
dc.subjectcarboxymethyl-kappa-carrageenan
dc.subjectsurface modification
dc.titleImproving blood compatibility of surfaces using tanfloc and carboxymethyl-kappa-carrageenan polyelectrolyte multilayers
dc.typeText
dcterms.embargo.expires2027-05-28
dcterms.embargo.terms2027-05-28
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorColorado State University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy (Ph.D.)

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