Archaeal isoprenoid biosynthesis
| dc.contributor.author | Liman, Lie Stefanus Geraldy, author | |
| dc.contributor.author | Santangelo, Thomas, advisor | |
| dc.contributor.author | Laybourn, Paul, committee member | |
| dc.contributor.author | Peebles, Christie, committee member | |
| dc.date.accessioned | 2018-09-10T20:04:15Z | |
| dc.date.available | 2018-09-10T20:04:15Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | Many high value natural products - including artemisinin, squalene, and farnesene – are isoprenoids. Efforts to commercially produce isoprenoids are often complicated by low concentrations of isoprenoid precursors and the toxicity of isoprenoids in common production platforms (i.e. bacteria and yeasts). Archaeal-based production platforms provide a potential solution to the precursor toxicity problems as archaea produce isoprenoids in large quantities to generate their unique membrane hydrocarbon chains. One roadblock to commercial archaeal isoprenoid production platforms is the uncharacterized pathway leading to isoprenoid precursor synthesis. This project details, genetically and biochemical, the first three steps in the proposed pathway of archaeal isoprenoid biosynthesis - from acetyl-CoA to mevalonate - in Thermococcus kodakarensis. | |
| dc.format.medium | born digital | |
| dc.format.medium | masters theses | |
| dc.identifier | Liman_colostate_0053N_14863.pdf | |
| dc.identifier.uri | https://hdl.handle.net/10217/191280 | |
| dc.language | English | |
| dc.language.iso | eng | |
| dc.publisher | Colorado State University. Libraries | |
| dc.relation.ispartof | 2000-2019 | |
| dc.rights | Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright. | |
| dc.subject | isoprenoid | |
| dc.subject | mevalonate | |
| dc.subject.lcsh | Archaea | |
| dc.title | Archaeal isoprenoid biosynthesis | |
| dc.type | Text | |
| dcterms.rights.dpla | This Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). | |
| thesis.degree.discipline | Biochemistry and Molecular Biology | |
| thesis.degree.grantor | Colorado State University | |
| thesis.degree.level | Masters | |
| thesis.degree.name | Master of Science (M.S.) |
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