Characterization of the performance of extraction chromatographic resins in high radiation environments

Abstract

The overall goal of this work is to analyze the impacts of ionizing radiation on extraction chromatography resins. This includes analyzing how the retention of a particular radionuclide changes as the resin is exposed to increasing doses of ionizing radiation (0 to 50 kGy). The effects of the system and strength of the aqueous mobile phase are also investigated with batch contact studies carried out on 3M nitric acid, 1M nitric acid, 3M hydrochloric acid, and 1M hydrochloric acid. The changes to the surface functionality of the extraction chromatography resins are investigated via FTIR measurements. Changes in the physical structure of the resins and their fragmentation patterns are investigated via MALDI-TOF-MS (Matrix Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry, referenced as MALDI colloquially).