Feed zone micromixing and its effect on continuous cultures of Saccharomyces cerevisiae
| dc.contributor.author | Mondani, Paul, author | |
| dc.contributor.author | Loftis, J. C., advisor | |
| dc.date.accessioned | 2023-07-24T18:55:43Z | |
| dc.date.available | 2023-07-24T18:55:43Z | |
| dc.date.issued | 1995 | |
| dc.description | Covers not scanned. | |
| dc.description | Print version deaccessioned 2023. | |
| dc.description.abstract | Inadequate mixing is known to be a common problem in the scale-up of bioprocesses, often leading to decreases in yield and productivity. To investigate the role of nutrient dispersion in continuous cultures, growth medium was fed into a laminar flow section of a loop that recirculates broth from a laboratory scale bioreactor. The intensity of micromixing at the feed site could be controlled by varying the axial distance a static mixer was placed upstream of the site. The intensity of the turbulent wake shed by the mixer was quantified by laser Doppler velocimetry and the Bourne dye reaction. By decreasing the size of the smallest turbulent eddy in the feed zone, less of the population is exposed to regions of either inadequate or excessive substrate concentrations. Yield vs. dilution rate curves were obtained through various mixing and feeding strategies. Reduced mixing was shown to delay the onset of the Crabtree effect and therefore improve the bioreactor's productivity. | |
| dc.format.medium | masters theses | |
| dc.identifier.uri | https://hdl.handle.net/10217/236767 | |
| dc.language | English | |
| dc.language.iso | eng | |
| dc.publisher | Colorado State University. Libraries | |
| dc.relation | Catalog record number (MMS ID): 991024448839703361 | |
| dc.relation | TP248.25.B55M65 1995 | |
| dc.relation.ispartof | 1980-1999 | |
| dc.rights | Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright. | |
| dc.subject.lcsh | Saccharomyces cerevisiae | |
| dc.subject.lcsh | Bioreactors | |
| dc.subject.lcsh | Fermentation | |
| dc.title | Feed zone micromixing and its effect on continuous cultures of Saccharomyces cerevisiae | |
| dc.type | Text | |
| dc.type | StillImage | |
| dcterms.rights.dpla | This Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). | |
| thesis.degree.discipline | Chemical and Bioresource Engineering | |
| thesis.degree.grantor | Colorado State University | |
| thesis.degree.level | Masters | |
| thesis.degree.name | Master of Science (M.S.) |
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